Summary of Study ST001354
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000924. The data can be accessed directly via it's Project DOI: 10.21228/M8810Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001354 |
| Study Title | 48 hours post-treatment L-Carnitine Pharmacometabolomics in Sepsis (CaPS) Patients |
| Study Type | multiple timepoints; patients with severe sepsis or septic shock treated with varying doses of L-carnitine or a saline placebo |
| Study Summary | phase II study of L-carnitine infusion for the treatment of vasopressor-dependent shock |
| Institute | University of Michigan |
| Department | Clinical Pharmacy |
| Laboratory | Stringer NMR Metabolomics Laboratory |
| Last Name | McHugh |
| First Name | Cora |
| Address | 428 Church St, Ann Arbor, MI, 48103, USA |
| NMRmetabolomics@umich.edu | |
| Phone | 7343530164 |
| Submit Date | 2020-04-09 |
| Num Groups | 4 |
| Total Subjects | 228 |
| Num Males | 128 |
| Num Females | 100 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2020-07-05 |
| Release Version | 1 |
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Project:
| Project ID: | PR000924 |
| Project DOI: | doi: 10.21228/M8810Q |
| Project Title: | 48 hours Post-treatment L-Carnitine Pharmacometabolomics in Sepsis (CaPS) Study |
| Project Type: | Quantitative NMR Metabolomics |
| Project Summary: | To utilize existing serum samples from the phase II clinical trial of L-carnitine treatment for severe sepsis to metabolically phenotype L-carnitine responders and non-responders. Methods: Serum samples collected prior to (T0) and after completion of the infusion (T24, T48) from patients randomized to either low (6 g), intermediate (12g), high (18g) L-carnitine or placebo for the treatment of vasopressor dependent septic shock were assayed by untargeted 1H-nuclear magnetic resonance metabolomics. |
| Institute: | University of Michigan |
| Laboratory: | Stringer NMR Metabolomics Laboratory |
| Last Name: | McHugh |
| First Name: | Cora |
| Address: | 428 Church St, Ann Arbor, MI, 48103, USA |
| Email: | NMRmetabolomics@umich.edu |
| Phone: | 7343530164 |
| Funding Source: | GM111400 |
| Contributors: | Michael A. Puskarich, Cora McHugh, Alla Karnovsky, Alan E. Jones, Kathleen A. Stringer |
