Summary of Study ST000337
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000269. The data can be accessed directly via it's Project DOI: 10.21228/M81307 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000337 |
| Study Title | Metabolomics Approach to Allograft Assessment in Liver Transplantation |
| Study Type | Retrospective analysis of biobanked liver tissue from organ donors |
| Study Summary | This pilot study is designed to apply several types of metabolomic analysis for liver allograft assessment with the aim of identifying candidate biomarkers for allograft function and to develop a methodology that could be applied to larger scale studies. The three main categories of metabolomic analysis are reflected in each of the specific aims, including a targeted profiling of central carbon metabolism, open lipidomic and metabolomic profiling for hypothesis generation and MALDI-IMS for tissue-based spatial analysis. Each of these approaches offers potential benefits that could be optimized in a protocol for larger scale studies depending the results of the pilot investigations. |
| Institute | Ochsner Multi-Organ Transplant Institute |
| Department | SECIM |
| Laboratory | Abdominal Organ Transplantation |
| Last Name | Seal |
| First Name | John |
| Address | 1514 Jefferson Highway, New Orleans, LA 70121 |
| John.Seal@ochsner.org | |
| Phone | 504-232-4253 |
| Submit Date | 2016-01-17 |
| Num Groups | 3 |
| Total Subjects | Targeted analysis and open profiling: Control group - standard criteria donor (N=15); Experimental group - donation-after-cardiac-death donors (N=10). MALDI-IMS - standard criteria donor (N=10) |
| Raw Data File Type(s) | raw(Thermo), d |
| Analysis Type Detail | LC-MS |
| Release Date | 2017-01-17 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Subject:
| Subject ID: | SU000357 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Genotype Strain: | Not applicable |
| Age Or Age Range: | Variable |
| Weight Or Weight Range: | Variable |
| Height Or Height Range: | Variable |
| Gender: | Variable |
| Human Race: | Variable |
| Human Ethnicity: | Variable |
| Human Trial Type: | Not applicable |
| Human Lifestyle Factors: | Not applicable |
| Human Medications: | Not applicable |
| Human Prescription Otc: | Not applicable |
| Human Smoking Status: | Not applicable |
| Human Alcohol Drug Use: | Not applicable |
| Human Nutrition: | Not applicable |
| Human Inclusion Criteria: | Deceased organ donor with consent for use of tissue for research |
| Human Exclusion Criteria: | None |
| Animal Animal Supplier: | in house/in house |
| Subject Comments: | Liver biopsy is routinely performed on livers used for solid organ transplantation. The tissue is from decedent subjects. Consent for use of tissue is obtained at the time of organ donation by the local organ procurement organization. |
| Species Group: | Mammals |
