Summary of Study ST000337

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000269. The data can be accessed directly via it's Project DOI: 10.21228/M81307 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000337
Study TitleMetabolomics Approach to Allograft Assessment in Liver Transplantation
Study TypeRetrospective analysis of biobanked liver tissue from organ donors
Study SummaryThis pilot study is designed to apply several types of metabolomic analysis for liver allograft assessment with the aim of identifying candidate biomarkers for allograft function and to develop a methodology that could be applied to larger scale studies. The three main categories of metabolomic analysis are reflected in each of the specific aims, including a targeted profiling of central carbon metabolism, open lipidomic and metabolomic profiling for hypothesis generation and MALDI-IMS for tissue-based spatial analysis. Each of these approaches offers potential benefits that could be optimized in a protocol for larger scale studies depending the results of the pilot investigations.
Ochsner Multi-Organ Transplant Institute
LaboratoryAbdominal Organ Transplantation
Last NameSeal
First NameJohn
Address1514 Jefferson Highway, New Orleans, LA 70121
Submit Date2016-01-17
Num Groups3
Total SubjectsTargeted analysis and open profiling: Control group - standard criteria donor (N=15); Experimental group - donation-after-cardiac-death donors (N=10). MALDI-IMS - standard criteria donor (N=10)
Raw Data File Type(s)raw(Thermo), d
Analysis Type DetailLC-MS
Release Date2017-01-17
Release Version1
John Seal John Seal application/zip

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Treatment ID:TR000371
Treatment Summary:Not Applicable
Treatment Protocol ID:Not Applicable
Treatment Protocol Filename:Not Applicable
Treatment Protocol Comments:Not Applicable
Treatment:Not Applicable
Treatment Compound:Not Applicable
Treatment Route:Not Applicable
Treatment Dose:Not Applicable
Treatment Dosevolume:Not Applicable
Treatment Doseduration:Not Applicable
Treatment Vehicle:Not Applicable