Summary of Study ST002696

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001668. The data can be accessed directly via it's Project DOI: 10.21228/M83H7N This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002696
Study TitleDeficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice
Study TypeMS Untargeted Lipidomics
Study SummaryGenetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. In addition, prior studies of mice harboring large, overlapping chromosomal deletions implicated Atp10A in the development of diet-induced obesity and insulin resistance. Here, we generated gene-specific Atp10A knockout mice and show that Atp10A-/- mice fed a high-fat diet did not gain excess weight relative to wild-type littermates. However, Atp10A-/- mice displayed female-specific dyslipidemia characterized by elevated plasma triglycerides, free fatty acids and cholesterol, as well as altered VLDL and HDL properties. We also observed increased circulating levels of several sphingolipid species along with reduced levels of eicosanoids and bile acids. The Atp10A-/- mice also displayed hepatic insulin resistance without perturbations to whole-body glucose homeostasis. Thus, ATP10A has a sex-specific role in regulating plasma lipid composition and maintaining hepatic liver insulin sensitivity in mice.
Vanderbilt University
LaboratoryCenter for Innovative Technology
Last NameMay
First NameJody
Address2301 Vanderbilt Place, Nashville, TN, 37235, USA
Submit Date2023-04-20
Num Groups2
Total Subjects10
Raw Data AvailableYes
Raw Data File Type(s)d, mzML
Analysis Type DetailLC-MS
Release Date2023-05-24
Release Version1
Jody May Jody May application/zip

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Treatment ID:TR002807
Treatment Summary:Mice were fasted for 5 hours (7AM-12PM). No additional treatments were administered.
Treatment:WT vs KO
Treatment Compound:n/a
Treatment Route:n/a
Treatment Dose:n/a
Treatment Dosevolume:n/a
Treatment Doseduration:n/a
Treatment Vehicle:n/a
Animal Vet Treatments:n/a
Animal Anesthesia:n/a
Animal Acclimation Duration:n/a
Animal Fasting:5 hour
Animal Endp Euthanasia:n/a
Animal Endp Tissue Coll List:Plasma was collected, via a retroorbital bleed or cardiac puncture
Animal Endp Clinical Signs:n/a